MedChemExpress - Model Empasiprubart -2579031-19-7

Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models[1][2].

Empasiprubart

MCE China：Empasiprubart

Brand：MedChemExpress (MCE)

Cat. No.HY-P990025

CAS：2579031-19-7

Synonyms：ARGX-117

Purity：97.93%

Storage：Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping：Shipping with dry ice.

Description：Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models.

In Vitro：Empasiprubar prevents complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection in an in vitro model[1]. Empasiprubar can inhibit C4 downstream complement activation induced by anti-GM1 antibody binding to motor neurons (MN) derived from induced pluripotent stem cells (iPSC) model[3].

In Vivo：Empasiprubart (0.5-30 mg/kg; once daily; 60 days; i.v.) targets the classical pathway (CP) and lectin pathway (LP) inhibition in crab eating macaques, without affecting the alternative pathway (AP)[1]. Empasiprubart (200 mg/kg; once; i.v.) can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models[2].

Species：Humanized

Isotype：Human IgG1 kappa

Recommend Isotype Controls：Human IgG1 kappa, Isotype Control

References：

[1]. Van de Walle I, et al. ARGX-117, a therapeutic complement inhibiting antibody targeting C2. J Allergy Clin Immunol. 2021 Apr;147(4):1420-1429.e7. [Content Brief]

[2]. Campbell CI, et al. Complement inhibition prevents glial nodal membrane injury in a GM1 antibody-mediated mouse model. Brain Commun. 2022 Nov 23;4(6):fcac306. [Content Brief]

[3]. Budding K, et al. Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy. Neurol Neuroimmunol Neuroinflamm. 2021 Nov 10;9(1):e1107. [Content Brief]

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MedChemExpress - Model Empasiprubart -2579031-19-7

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Empasiprubart