MedChemExpress - Model MRT-2359 - 2803881-11-8
MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research[1][2][3][4][5].MCE products for research use only. We do not sell to patients.
MRT-2359
MCE China：MRT-2359
Brand：MedChemExpress (MCE)
Cat. No.HY-153356
CAS：2803881-11-8
Purity：99.91%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research.
In Vitro：MRT-2359 demonstrates significant selective activity in MYC-driven lung cancer. In a broad range of cancer cell lines, MRT-2359 exhibits pronounced and preferential anti-proliferative activity towards those cell lines with high N-Myc or L-Myc expression, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cell lines. However, MRT-2359 shows minimal to no effect on cell lines with low N-Myc or L-Myc expression[4].
In Vivo：MRT-2359 completely degrades GSPT1 in high N-MYC non-small cell lung cancer (NSCLC) transplanted tumors and PDX models, reduces the expression level of N-Myc protein, consequently leading to a reduction in tumor size[3]. MRT-2359 (10 mg/kg; Oral gavage (p.o.); 5 days on, 9 days off, 4 weeks) can completely regress tumors in immunocompromised xenografted mouse models of AR-V7-positive cell lines 22RV1 and NCI-H660[5].
IC50 & Target：IC50: >30 nM and [1] In Vitro MRT-2359 demonstrates significant selective activity in MYC-driven lung cancer. In a broad range of cancer cell lines, MRT-2359 exhibits pronounced and preferential anti-proliferative activity towards those cell lines with high N-Myc or L-Myc expression, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cell lines. However, MRT-2359 shows minimal to no effect on cell lines with low N-Myc or L-Myc expression[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MRT-2359 Related Antibodies
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