MedChemExpress LLC (MCE)

MedChemExpress - Model 7-Nitroindazole - 2942-42-9

7-Nitroindazole is a selective and BBB-penatrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole has anti-injurious and neuroprotective properties[1][2][3][4].

7-Nitroindazole

MCE China：7-Nitroindazole

Brand：MedChemExpress (MCE)

Cat. No.HY-69019

CAS：2942-42-9

Purity：99.04%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：7-Nitroindazole is a selective and BBB-penatrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole has anti-injurious and neuroprotective properties.

In Vitro：7-Nitroindazole (0.01-100 μM) has obvious inhibitory effect on cerebellar NOS (IC50: 0.47 μM), and is more effective than L-NAME (HY-18729A) (IC50: 0.87 μM) and L-NMMA (HY-18732) (IC50: 2.37 μM)[1].

In Vivo：7-Nitroindazole (10-80 mg/kg; Intraperitoneal injection; Single dose) has an anti-injury and anti-nociceptive effect in a formalin-induced mouse pain model without increasing blood pressure[1]. 7-Nitroindazole (25 mg/kg; Subcutaneous injection; 25 days) improves L-DOPA (HY-N0304)-induced dyskinesias in non-human primate models of Parkinson's disease[2]. 7-Nitroindazole (5-20 mg/kg; Intraperitoneal injection; 6 weeks) improves the learning and memory of hypothyroidism rats[3]. 7-Nitroindazole (30 mg/kg; Intraperitoneal injection; Single dose) enhances Fos immune response induced by muscle proprioceptive signaling within distinctive regions of the spinal cord in rats[4].

IC50 & Target：nNOS

References：

[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7. [Content Brief]

[2]. Herrero MT, et al. 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. Open Biol. 2023 May;13(5):220370. [Content Brief]

[3]. Memarpour S, et al. Neuronal Nitric Oxide Inhibitor 7-Nitroindazole Improved Brain-Derived Neurotrophic Factor and Attenuated Brain Tissues Oxidative Damage and Learning and Memory Impairments of Hypothyroid Juvenile Rats. Neurochem Res. 2020 Nov;45(11):2775-2785. [Content Brief]

[4]. ilyavskii AI,et al. 7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord. Muscle Nerve. 2012 Apr;45(4):597-602. [Content Brief]

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