MedChemExpress - Model p-Cresyl sulfate -3233-58-7

p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD).

p-Cresyl sulfate

MCE China：p-Cresyl sulfate

Brand：MedChemExpress (MCE)

Cat. No.HY-111431

CAS：3233-58-7

Synonyms：p-Tolyl sulfate

Purity：99.87%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways.

In Vitro：p-Cresyl sulfate (0-500 μM; 0-48 h) shows antiproliferation activity in a dose- and time-dependent manner[1]. p-Cresyl sulfate (100, 200 μM; 1, 3, 5 days) increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α[1]. p-Cresyl sulfate (40 µg/mL) inhibits lipogenesis and increases lipolysis in adipocytes in 3T3-L1 cells[2]. p-Cresyl sulfate (0.125 mM, 24 h) induces osteoblast dysfunction through activating JNK and p38 MAPK pathways[3]. p-Cresyl sulfate (0-0.5 mM; 60 min) induces ROS production in primary osteoblastic cells[3].

In Vivo：p-Cresyl sulfate (10 mg/kg; IP; twice daily for 4 weeks) exhibits hyperglycemia and hypercholesterolemia[2].

IC50 & Target：Microbial Metabolite Human Endogenous Metabolite

References：

[1]. Wu TK, et al. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals. Sci Rep. 2019 Mar 1;9(1):3207. [Content Brief]

[2]. Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24(1):88-99. [Content Brief]

[3]. Tanaka H, et al. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56(2):347-54. [Content Brief]

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MedChemExpress - Model p-Cresyl sulfate -3233-58-7

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p-Cresyl sulfate