MedChemExpress - Model (E,E)-Bisdemethoxycurcumin - 33171-05-0
(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities[1][2][3][4][5][6].MCE products for research use only. We do not sell to patients.
(E,E)-Bisdemethoxycurcumin
MCE China：(E,E)-Bisdemethoxycurcumin
Brand：MedChemExpress (MCE)
Cat. No.HY-N0007
CAS：33171-05-0
Synonyms：(E,E)-Curcumin III; (E,E)-Didemethoxycurcumin
Purity：98.0%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities.
In Vitro：Bisdemethoxycurcumin (1-10 μM; 5 h) significantly inhibits HT1080 cancer cell invasion, but does not affect cell migration[5].Bisdemethoxycurcumin (1-10 μM; 24 h) inhibits the secret of MMP-9 in HT1080 cells, and affects cancer cell invasion and metastasis[5].Bisdemethoxycurcumin (5-50 μM; 24 h) Bisdemethoxycurcumin (5-50 μM; 24 h) significantly inhibits collagenase, MMP-2 and MMP-9 activities in HT1080, but does not inhibit uPA activity[5].Bisdemethoxycurcumin (25 μM; 18 h, 24 h) arrests cell cycle at G1 phase, and (5-25 μM) inhibits the expression of C/EBPα and PPARγ in 3T3-L1 adipocyte 270 differentiation[6].Bisdemethoxycurcumin inhibits lipid accumulation in adipocytes, primarily by attenuating mitotic clonal expansion (MCE) to inhibit early lipogenesis[6].
In Vivo：Bisdemethoxycurcumin (0.5% in diet; 15 weeks) significantly reduces both final body weight and body weight gain in HFD-induced obese mice[6].
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References：
[1]. Lee PJ, et al. Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2. Molecules. 2015 Jan 14;20(1):1277-92. [Content Brief]
[2]. Chen J, et al. Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells. Food Funct. 2014 Dec 24. [Content Brief]
[3]. Luo C, et al. Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett. 2015 Jan;9(1):270-274. [Content Brief]
[4]. Li YB, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714. [Content Brief]
[5]. Yodkeeree S, et al. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem. 2009 Feb;20(2):87-95. [Content Brief]
[6]. Lai CS, et al. Bisdemethoxycurcumin Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Fed C57BL/6 Mice. J Agric Food Chem. 2016 Feb 3;64(4):821-30. [Content Brief]
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