MedChemExpress - Model D-Mannose - 3458-28-4
D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation[1][2][3].MCE products for research use only. We do not sell to patients.
D-Mannose
MCE China：D-Mannose
Brand：MedChemExpress (MCE)
Cat. No.HY-N0379
CAS：3458-28-4
Purity：98.0%
Storage：4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation.
In Vitro：D-Mannose (5.5, 11, 25 mM, 24 h) inhibits macrophage activation by inhibiting the production of IL-1β[1]. D-Mannose (25 mM, 24-72 h) stimulates Treg cell differentiation in human and mouse cells by promoting TGF-β activation and inhibiting immunopathology[2].
In Vivo：D-Mannose (2g/kg, intraperitoneally injected 6 times per hour, killed 3 h later) can protect mice from DSS-induced ulcerative colitis [1]. D-Mannose (1.1 M D-mannose dissolved in water for 2 months) alleviates bone loss in mice through Treg cell proliferation and intestinal microbiome-dependent anti-inflammatory effects[3].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. Torretta S, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020 Dec 11;11(1):6343. [Content Brief]
[2]. Zhang D, et al. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23(9):1036-1045. [Content Brief]
[3]. Liu H, et al. D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Ther Adv Chronic Dis. 2020 Apr 17;11:2040622320912661. [Content Brief]
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