MedChemExpress LLC (MCE)

MedChemExpress - Model Tolperisone hydrochloride - 3644-61-9

Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity[1].

Tolperisone hydrochloride

MCE China：Tolperisone hydrochloride

Brand：MedChemExpress (MCE)

Cat. No.HY-B1139

CAS：3644-61-9

Purity：99.94%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity.

In Vitro：Tolperisone (0-128 μM, 48 h) hydrochloride induces UPR-mediated cancer cell death by directly targeting LSD1, with IC50s of 10-40 μM[1]. Tolperisone inhibits LSD1 activity with an IC50 of 31.09 µM[1]. Tolperisone (100 μM, 48 h) induces cancer cell cycle arrest and apoptosis in AGS, A375, 8505C, and RKO cells[1]. Tolperisone (100 μM, 12 h) repolarizes M2 macrophages into M1 phenotype[1].

In Vivo：Tolperisone (25-100 mg/kg) shows antinociceptive effect in partial sciatic nerve ligation (pSNL) evoked neuropathic pain rats[2]. Tolperisone (60 mg/kg, once a day for 1 week) hydrochloride inhibits tumor growth in A375 cell-derived xenograft mouse model[1].

References：

[1]. Jiang W, et al. Tolperisone induces UPR-mediated tumor inhibition and synergizes with proteasome inhibitor and immunotherapy by targeting LSD1. Expert Opin Ther Targets. 2023 Jul-Dec;27(9):879-895. [Content Brief]

[2]. Lakatos PP, et al. The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action. Int J Mol Sci. 2022 Aug 24;23(17):9564. [Content Brief]

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