MedChemExpress - Model Daucosterol - 474-58-8
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway[1][2][3].MCE products for research use only. We do not sell to patients.
Daucosterol
MCE China：Daucosterol
Brand：MedChemExpress (MCE)
Cat. No.HY-N0410
CAS：474-58-8
Synonyms：Eleutheroside A; β-Sitosterol β-D-glucoside
Purity：93.98%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway.
In Vitro：Daucosterol (0.01-100 μM, 48 h) inhibits the proliferation of MCF-7, AGS, MGC803 and BGC823 cells in a dose-dependent manner, with IC50s of 19.96 μM, 3.13 μM, 24.19 μM and 16.95 μM, respectively[1]. Daucosterol (50 μM, 24 h) significantly increases ROS production in MCF-7 and BGC823 cells[1]. Daucosterol (0-80 μM, 48 h) inhibits proliferation and promotes apoptosis in PC3 and LNCap cells[2].
In Vivo：Daucosterol (0.5-2.5 mg/kg, p.o., once per day for 7 days) significantly inhibits the H22 tumor growth in ICR mice inoculated with H22 hepatoma cells[1].
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References：
[1]. Zhao C, et al. Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner. Life Sci. 2015 Sep 15;137:37-43. [Content Brief]
[2]. Gao P, et al. Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation. Biosci Trends. 2019 May 12;13(2):160-167. [Content Brief]
[3]. Jiang LH, et al. Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway. J Steroid Biochem Mol Biol. 2015 Aug;152:45-52. [Content Brief]
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