MCE products for research use only. We do not sell to patients.

Kaempferide

MCE China：Kaempferide

Brand：MedChemExpress (MCE)

Cat. No.HY-15449

CAS：491-54-3

Synonyms：Kaempferol 4'-O-methyl ether

Purity：99.80%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research.

In Vitro：Kaempferid is toxic in HCC cell lines (HepG2:IC50 = 27.94 µM; Huh7: IC50 = 25.65 µM; N1S1: IC50 = 15.18 µM)[1]. Kaempferid (5, 20 μM; 48 h) reduces lipid accumulation and oxidative stress in HepG2 cells induced by oral acid (OA) (0.5 mM) (HY-N1446)[2]. Kaempferide promotes osteogenesis through the FoxO1/β-catenin signaling pathway [3]. Kaempferide (10-15 μM; 24 h) is toxic in HeLa cells with an IC50 of 16 μM and can induce apoptosis[6].

In Vivo：Kaempferid (25 mg/kg; IV; three times a week) has anticancer activity in SD (Sprague Dawley) rats[1]. Kaempferide (10 mg/kg; supplemented in daily diet, once daily for16 weeks) ameliorates oxidative stress and inflammation in obese C57BL/6J mice by inhibiting the TLR4/i-κBα/NF-κB pathway and can alleviate Obesity and glucose and lipid metabolism disorders[4]. Kaempferide (0.1-0.3 mg/kg; injection, single dose) alleviates myocardial ischemia/reperfusion injury by activating PI3K/Akt/GSK-3β pathway in Sprague Dawley (I/R)-induced rats[5].

Hot selling product：CCT241533 (hydrochloride)  | Diphenhydramine (hydrochloride)  | Co(III) protoporphyrin IX chloride  | Aripiprazole  | SRT 1460  | Cilazapril (monohydrate)  | Amiodarone (hydrochloride)  | Mupadolimab  | Uridine 5'-monophosphate  | Chlortetracycline (hydrochloride)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Chandrababu G, et al. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2023: 1-7.

[2]. Tie F, et al. Kaempferol and kaempferide attenuate oleic acid-induced lipid accumulation and oxidative stress in HepG2 cells[J]. International Journal of Molecular Sciences, 2021, 22(16): 8847.  [Content Brief]

[3]. Ma X, et al. Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway[J]. European Journal of Pharmacology, 2021, 911: 174555.  [Content Brief]

[4]. Tang H, et al. Kaempferide improves oxidative stress and inflammation by inhibiting the TLR4/IκBα/NF-κB pathway in obese mice[J]. Iranian Journal of Basic Medical Sciences, 2021, 24(4): 493.  [Content Brief]

[5]. Wang D, et al. Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway. Mediators Inflamm. 2017;2017:5278218.  [Content Brief]

[6]. Nath L R, et al. Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe[J]. RSC advances, 2015, 5(122): 100912-100922.