MedChemExpress - Model Lactate - 50-21-5
Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2].MCE products for research use only. We do not sell to patients.
Lactate
MCE China：Lactate
Brand：MedChemExpress (MCE)
Cat. No.HY-B2227
CAS：50-21-5
Synonyms：Lactic acid
Purity：91.61%
Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity.
In Vitro：Lactate (Lactic acid; 20 mM; 24, 48 h) results in a significant decrease in cell proliferation and migration, acting and switching cell metabolism toward oxidative phosphorylation[1]. Lactate (20 mM; 24 h) shows an increase in the protein and mRNA expression levels of MCT1 and HCAR1[1].
In Vivo：Lactate (Lactic acid; 1.6 g/kg; pH 7.4; subcutaneous; daily from Day 8 to 30 days) shows CD8+ T cell-dependent tumor growth inhibition in MC38 colon cancer model[2]. Note: The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24. [Content Brief]
[2]. Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981. [Content Brief]
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