MedChemExpress LLC (MCE)

MedChemExpress - Model Tributyrin - 60-01-5

Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].

Tributyrin

MCE China：Tributyrin

Brand：MedChemExpress (MCE)

Cat. No.HY-W011404

CAS：60-01-5

Synonyms：Glyceryl tributyrate

Purity：98.91%

Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects.

In Vitro：Tributyrin (0.8 mM, 48 hours) induces significant growth inhibition in PC-3 cells[3]. Tributyrin (0.5-5 mM, 48 hours) causes G1 cell cycle arrest in LNCaP cells[3]. Tributyrin (0.1-5 mM, 48 hours) induces higher apoptosis rates in PC-3 and TSU-PR1 cells[3]. Tributyrin (1-5 mM, 48 hours) induces prostate-specific antigen expression in LNCaP cells, suggesting its differentiation effect[3]. Tributyrin (1 mM, 24 hours) directly inhibits the production of TNF-α and IL-1β in RAW 264.7 cells under LPS stimulation[6].

In Vivo：Tributyrin (2.0 g/kg, p.o., three times per week for 6 weeks) improves the metabolic and inflammatory states in high-fat diet-induced obese mice[4]. Tributyrin (0.3 g/kg, p.o., once daily for 11 days) significantly improves gut microbiota dysbiosis and intestinal injury in a Ceftriaxone (HY-B0712)-induced gut dysfunction mouse model[5].

IC50 & Target：IL-1β

References：

[1]. T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131(6):1839-43. [Content Brief]

[2]. Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20(1):195-200. [Content Brief]

[3]. Maier S, et al. Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines. Int J Cancer. 2000 Oct 15;88(2):245-51. [Content Brief]

[4]. Sato FT, et al. Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism. Cells. 2020 Sep 1;9(9):2007. [Content Brief]

[5]. Yang N, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS One. 2023 Jul 31;18(7):e0289364. [Content Brief]

[6]. Vinolo MA, et al. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E272-82. [Content Brief]

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