MedChemExpress - Model Pentoxifylline - 6493-05-6
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].MCE products for research use only. We do not sell to patients.
Pentoxifylline
MCE China：Pentoxifylline
Brand：MedChemExpress (MCE)
Cat. No.HY-B0715
CAS：6493-05-6
Synonyms：BL-191; PTX; Oxpentifylline
Purity：99.92%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.
In Vitro：Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner[3]. Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells[3]. Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells[3]. Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase[3]. Pentoxifylline results in high LC3-II/LC3-ratio[3].
In Vivo：Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment[4].
IC50 & Target：PDE[1] Cellular Effect Cell Line Type Value Description References
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References：
[1]. Iffat Hassan, et al. Pentoxifylline and its applications in dermatology. Indian Dermatol Online J. 2014 Oct-Dec; 5(4): 510–516. [Content Brief]
[2]. A Ward, et al. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987 Jul;34(1):50-97. [Content Brief]
[3]. Yessica Cristina Castellanos-Esparza, et al. Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells. Int J Oncol. 2018 Apr;52(4):1246-1254. [Content Brief]
[4]. Shabnam Movassaghi, et al. Effect of Pentoxifylline on Ischemia- induced Brain Damage and Spatial Memory Impairment in Rat. Iran J Basic Med Sci. 2012 Sep-Oct; 15(5): 1083-1090. [Content Brief]
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