MedChemExpress LLC (MCE)

MedChemExpress - Model Goserelin - 65807-02-5

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

Goserelin

MCE China：Goserelin

Brand：MedChemExpress (MCE)

Cat. No.HY-13673

CAS：65807-02-5

Synonyms：ICI 118630

Storage：Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

In Vitro：Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1]. Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1]. Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

In Vivo：Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

IC50 & Target：GnRH[1] In Vitro Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1]. Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1]. Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Goserelin Related Antibodies Apoptosis Analysis[1] Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)

References：

[1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042. [Content Brief]

[2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32. [Content Brief]

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