MedChemExpress LLC (MCE)

MedChemExpress - Model Thiamine hydrochloride - 67-03-8

Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis[1][2][3][4][5][6][7].

Thiamine hydrochloride

MCE China：Thiamine hydrochloride

Brand：MedChemExpress (MCE)

Cat. No.HY-N0680

CAS：67-03-8

Synonyms：Thiamine chloride hydrochloride; Vitamin B1 hydrochloride

Purity：99.97%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis.

In Vitro：Thiamine (0.125-2 μg/mL, 24 h) hydrochloride increases cellular PDH activities in breast cancer cells and increases basal, maximum, and ATP production oxygen consumption rate for the MCF7 cells[2]. Thiamine (10-100 mM, 5 days) hydrochloride reduces proliferation in cancer cell lines SK-N-BE and Panc-1[3]. Thiamine (200 μM) hydrochloride protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells[4].

In Vivo：Thiamine (300 µg/kg, alternate days during the last 14 days of the experiment) hydrochloride ameliorates Scopolamine-induced memory dysfunction via Nrf-2/TLR4 signaling pathway in adult mice[5]. Thiamine (150-200 mg/kg, i.p., 21 days) hydrochloride shows anti-inflammatory and antihyperalgesic effects in adjuvant-induced arthritis wistar rats[6]. Thiamine (20 mg/kg/d, i.p., 5 days) hydrochloride attenuates macroscopic parameters of colons and reduces total colitis index in rats with colitis[7].

IC50 & Target：TLR4

References：

[1]. Moulin M, et al. Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14622-7. [Content Brief]

[2]. Liu X, et al. The Effects of Thiamine on Breast Cancer Cells. Molecules. 2018 Jun 16;23(6):1464. [Content Brief]

[3]. Hanberry BS, Berger R, Zastre JA. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol. 2014 Mar;73(3):585-94. [Content Brief]

[4]. Avena R, et al. Thiamine (Vitamin B1) protects against glucose- and insulin-mediated proliferation of human infragenicular arterial smooth muscle cells. Ann Vasc Surg. 2000 Jan;14(1):37-43. [Content Brief]

[5]. Nasir A, et al. Vitamin B1 via Nrf-2/TLR4 signaling pathway ameliorates scopolamine-induced memory dysfunction in adult mice. Arabian Journal of Chemistry, 2024, 17(1): 105350.

[6]. Zaringhalam J, et al. Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis. Basic Clin Neurosci. 2016 Oct;7(4):331-340. [Content Brief]

[7]. Dalayeli N, et al. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats. Int J Prev Med. 2024 Nov 28;15:61. [Content Brief]

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