MedChemExpress LLC (MCE)

MedChemExpress - Model Elamipretide - 736992-21-5

Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2].

Elamipretide

MCE China：Elamipretide

Brand：MedChemExpress (MCE)

Cat. No.HY-P0125

CAS：736992-21-5

Synonyms：MTP-131; RX-31; SS-31

Purity：99.54%

Storage：Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury.

In Vivo：Elamipretide (5 mg/kg, i.p., once daily for 3 days) exhibits neuroprotective effects, protects the hippocampus from mitochondrial dysfunction, and attenuates the oxidative stress and inflammatory response in Lipopolysaccharide (HY-D1056)-induced cognitive impairment in C57BL/6 mice model[1].

IC50 & Target：Cardiolipin peroxidase[1] In Vivo Elamipretide (5 mg/kg, i.p., once daily for 3 days) exhibits neuroprotective effects, protects the hippocampus from mitochondrial dysfunction, and attenuates the oxidative stress and inflammatory response in Lipopolysaccharide (HY-D1056)-induced cognitive impairment in C57BL/6 mice model[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: LPS-induced cognitive impairment in C57BL/6 mice model[1]

Sequence：{d-Arg}-{Dmt}-Lys-Phe-NH2

References：

[1]. Zhao W, et al., Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. J Neuroinflammation. 2019 Nov 20;16(1):230. [Content Brief]

[2]. Sabbah HN,et al., Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure. Circ Heart Fail. 2016 Feb;9(2):e002206. [Content Brief]

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