MedChemExpress LLC (MCE)

MedChemExpress - Model Bisphenol A - 80-05-7

Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cancers, cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[1][2][3][4][5][6][7][8][9].

Bisphenol A

MCE China：Bisphenol A

Brand：MedChemExpress (MCE)

Cat. No.HY-18260

CAS：80-05-7

Purity：99.75%

Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cancers, cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders.

In Vitro：Bisphenol A significantly reduces the viability, increases and decreases levels of intracellular ROS production and antioxidant capacity, respectively, in KGN cells[1]. Bisphenol A (100 fM-100 μM, 24-72 h) decreases granulosa cell viability and induces apoptosis and G2-to-M arrest of ovarian granulosa cells[3]. Bisphenol A (0-400 μM, 24 h) suppresses proliferation and induces apoptosis in human colon cancer cells HCT116 through mitochondrial and MAPK/AKT pathways[4]. Bisphenol A (0.5-12.5 μM, 5 days) significantly inhibits RANKL-induced, TRAP-positive multinucleated cell formation in bone marrow-derived macrophages and RAW 264.7 cell cultures[5]. Bisphenol A (0.5-12.5 μM) suppresses ALP activities and bone nodule formation in MC3T3-E1 cells[5]. Bisphenol A (0.06-500 μM, 1 h) induces morphological and biochemical alterations in human peripheral blood mononuclear cells[6]. Bisphenol A (0.0020-2.0 μM, 24-48 h) decreases viability and induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells[7].

In Vivo：Bisphenol A (200 mg/kg/day, s.c., 4 weeks) significantly decreases testis, epididymis, prostate and seminal vesicle weights, and the testicular daily sperm production in Jcl:Wistar rats[8]. Bisphenol A (500-1250 mg/kg/day, gastric intubation, gestational days 6 through 15) induces maternal mortality and fetal toxicity in CD-1 mice[9].

References：

[1]. Huang M, et al. Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells. Chemosphere. 2020 Apr 9;253:126707. [Content Brief]

[2]. Rubin BS, et al. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):27-34. [Content Brief]

[3]. Xu J, et al. Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells. Biochem Biophys Res Commun. 2002 Mar 29;292(2):456-62. [Content Brief]

[4]. Qu W, et al. Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways. Life Sci. 2018 Sep 1;208:167-174. [Content Brief]

[5]. Hwang JK, et al. Bisphenol A reduces differentiation and stimulates apoptosis of osteoclasts and osteoblasts. Life Sci. 2013 Sep 17;93(9-11):367-72. [Content Brief]

[6]. Michałowicz J, et al. Bisphenol A and its analogs induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study). Toxicol In Vitro. 2015 Oct;29(7):1464-72. [Content Brief]

[7]. Lin Y, et al. Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells. Cell Death Dis. 2013 Jan 17;4(1):e460. [Content Brief]

[8]. Takahashi O, et al. Testicular toxicity of dietarily or parenterally administered bisphenol A in rats and mice. Food Chem Toxicol. 2003 Jul;41(7):1035-44. [Content Brief]

[9]. Morrissey RE, et al. The developmental toxicity of bisphenol A in rats and mice. Fundam Appl Toxicol. 1987 May;8(4):571-82. [Content Brief]

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