MedChemExpress LLC (MCE)

MedChemExpress - Model Hirudin - 8001-27-2

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others[1].

Hirudin

MCE China：Hirudin

Brand：MedChemExpress (MCE)

Cat. No.HY-P2813

CAS：8001-27-2

Purity：95.0%

Storage：-80°C

Shipping：Shipping with dry ice.

Description：Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others.

In Vitro：Hirudin inhibits the activity of thrombin, deprives the ability of thrombin to cleave fibrinogen, prevents the formation of fibrin and the cross-linking polymerization process of fibrin monomer in internal and external coagulation pathway[1]. Hirudin reduces cell apoptosis of human microvascular endothelial cells (HMVECs) and suppresses the expression of p-JAK2 via antagonizing thrombin[1]. Hirudin inhibits VEGF-Notch pathway and cell proliferation of HMVECs at high doses[1]. Hirudin (3-10 mg/mL) reverses the abnormal proliferation and fibrosis in HK-2 cells caused by TGF-β1[1]. Hirudin depresses the myocardial fibroblasts induced by angiotensin II by dose-dependently inhibits oxidative stress, regulates fibrosis-related factors, and represses the ERK1/2 pathway[1].

In Vivo：Hirudin increases the viability of rat random skin flap and reduces inflammatory responses[1]. Hirudin promotes the wound healing in SD rats after laser surgery[1]. Hirudin (10 and 15 mg/kg; i.g. once daily for 21 days) improves renal interstitial fibrosis to reduce renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice[2].

References：

[1]. Junren C,et al. Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review. Front Pharmacol. 2021 Apr 16;12:660757. [Content Brief]

[2]. Xie Y, et al. Hirudin improves renal interstitial fibrosis by reducing renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice. Int Immunopharmacol. 2020 Apr;81:106249. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。