MedChemExpress LLC (MCE)

MedChemExpress - Model D-Panthenol - 81-13-0

D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

D-Panthenol

MCE China：D-Panthenol

Brand：MedChemExpress (MCE)

Cat. No.HY-B1391

CAS：81-13-0

Synonyms：Dexpanthenol

Purity：99.98%

Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

In Vitro：D-panthenol exhibits neuroprotective activity against tBHP (0-100 μM) and FESO4 (0.5 mM) induced oxidation in mitochondria through inhibiting lipid peroxidation, thereby improves mitochondrial metabolism, reverses redox potential of the glutathione system and decreases the level of S-glutathionylated proteins[4].

In Vivo：D-panthenol (200 mg/kg, i.p. for 7 days) enhances tolerance of kidney tissues against oxidative damage through limited lipid peroxidation and SOD activity in Rhabdomyolysis-Induced AKI in Wistar mice[2]. D-panthenol (200 mg/kg, i.p. for 7 days) exhibits nephroprotective effect through inhibiting inflammatory processes with decreased MPO activity and leukocyte infiltration in Rhabdomyolysis-Induced AKI in Wistar mice [2]. D-panthenol (4 mg as a spray, twice a day for 14 days) promotes wound healing through retaining the environment moisture, promoting tissue repair and regeneration in streptozotocin-induced diabetes mellitus C57BL/6 mice and db/db mice[3].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Oguz A, et al. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Int Surg. 2015 Apr;100(4):656-61. [Content Brief]

[2]. Semenovich DS, et al., Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury. Int J Mol Sci. 2022 Oct 14;23(20):12273. [Content Brief]

[3]. linova E, et al., Cerium-Containing N-Acetyl-6-Aminohexanoic Acid Formulation Accelerates Wound Reparation in Diabetic Animals. Biomolecules. 2021 Jun 3;11(6):834. [Content Brief]

[4]. Semenovich DS, et al., Effects of Panthenol and N-Acetylcysteine on Changes in the Redox State of Brain Mitochondria under Oxidative Stress In Vitro. Antioxidants (Basel). 2021 Oct 27;10(11):1699. [Content Brief]

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