MedChemExpress - Model TPI-287 - 849213-15-6
TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1].MCE products for research use only. We do not sell to patients.
TPI-287
MCE China：TPI-287
Brand：MedChemExpress (MCE)
Cat. No.HY-126899
CAS：849213-15-6
Purity：99.47%
Storage：4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain.
In Vivo：TPI-287(i.v., 18 mg/kg, every 4 days, 41 days) can effectively reduce tumor volume and inhibit tumor growth in mouse tumor models inoculated with 231-BR breast cancer cells[1].
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References：
[1]. Daniel P Fitzgerald, et al. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67. [Content Brief]
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