MedChemExpress - Model Gelatins - 9000-70-8
Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy[1][2][3].MCE products for research use only. We do not sell to patients.
Gelatins
MCE China：Gelatins
Brand：MedChemExpress (MCE)
Cat. No.HY-Y1365
CAS：9000-70-8
Purity：98.0%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy[1][2][3].
In Vitro：Gelatins (6-12 %, 5 days) forms gelatin@NWF Derivatives serve as long-term storage scaffolds to promote the formation of prostate tumor cell spheroids for culturing tumor cells[3]. Gelatins (0-200 μg/mL, 24 h) can enhance cell adhesion, growth, and wound healing of HaCaT cells, and protect HaCaT cells from H2O2 induced cell damage[5].
In Vivo：Gelatins (20 μg/kg; i.p.) has a good improvement effect on exercise recovery of spinal cord injury in Wistar rats by forming Au NPs/Gelatin nanocomposite[1]. Gelatins has excellent hemostatic effects on rat femoral artery injury after crosslinking with biocompatible dialdehyde starch (DAS) to synthesize aminated gelatin sponge[2]. Gelatins (10 mg/kg; once every two days; 14 days; i.v.) is modified with PEG to form a pH/enzyme responsive complex, which specifically delivers doxorubicin (DOX) (HY-15142A) and exhibits anti-tumor activity in S180 ectopic tumor mice[4].
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References：
[3]. Fu J, et al. Lyophilized Gelatin@non-Woven Scaffold to Promote Spheroids Formation and Enrich Cancer Stem Cell Incidence. Nanomaterials (Basel). 2022 Feb 28;12(5):808. [Content Brief]
[4]. Dong L, et al. A pH/enzyme-responsive tumor-specific delivery system for doxorubicin. Biomaterials. 2010 Aug;31(24):6309-16. [Content Brief]
[5]. Huang CY, et al. Enhancement of Cell Adhesion, Cell Growth, Wound Healing, and Oxidative Protection by Gelatins Extracted from Extrusion-Pretreated Tilapia (Oreochromis sp.) Fish Scale. Molecules. 2018 Sep 20;23(10):2406. [Content Brief]
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