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MedChemExpressModel Tigatuzumab - 918127-53-4

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Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer[1].
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Tigatuzumab

MCE China:Tigatuzumab

Brand:MedChemExpress (MCE)

Cat. No.HY-P99270

CAS:918127-53-4

Synonyms:CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody

Purity:95.00%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer.

In Vitro:Tigatuzumab is sensitive to MIA PaCa-2 cells and BxPC-3 cells with IC50 values of 2.95 and 8.21 μg/mL, respectively[1]. Tigatuzumab (3-8 μg/mL; 5 h) induces apoptosis of cancer cells[1].

In Vivo:Tigatuzumab (3 mg/kg; i.v. weekly for 4 weeks) effectively represses the tumor growth in human pancreatic cancer MIA PaCa-2-RFP orthotopic mouse model[1].

Species:Humanized

Isotype:Human IgG1 kappa

Recommend Isotype Controls:Human IgG1 kappa, Isotype Control

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References:

[1]. Yamamoto J, et al. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 Nov 1;492:174-184.  [Content Brief]

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