MedChemExpress LLC (MCE)

MedChemExpress - Model Eugenol acetate - 93-28-7

Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis[1][2][3][4].

Eugenol acetate

MCE China：Eugenol acetate

Brand：MedChemExpress (MCE)

Cat. No.HY-W014612

CAS：93-28-7

Synonyms：Acetyleugenol

Purity：99.76%

Storage：4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis.

In Vivo：Eugenol acetate (15% v/v for 30 μL; twice per wk for 28 wk) causes increased expression of p53 and p21WAF1 in mouse skin, and apoptosis in cancer tissue[2].Eugenol acetate (3-300 mg/kg; po or ip, single dose) can exert an analgesic effect and inhibit different mouse acute pain models caused by acetic acid, glutamate, and kainic acid, respectively[3].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Musthafa KS, et al. Antifungal potential of eugenyl acetate against clinical isolates of Candida species. Microb Pathog. 2016 Oct;99:19-29. [Content Brief]

[2]. Kaur G, et al. Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis. Mol Carcinog. 2010 Mar;49(3):290-301. [Content Brief]

[3]. Dal Bó W, et al. Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-α) pathways. Fundam Clin Pharmacol. 2013 Oct;27(5):517-25 [Content Brief]

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