SPACEGEN - ALK/ROS1/RET Gene Fusion Detection Kit (Mutiplex Fluorescence PCR)

Gene fusion refers to a new hybrid gene formed by connecting parts or all of two different genes' sequences. The encoded fusion protein produced by this gene fusion can mediate the occurrence and development of tumors. In non-small cell lung cancer (NSCLC), gene fusions, as an important class of molecular mutations, serve as ideal targets for targeted therapy. Therefore, precise detection of gene fusions in NSCLC is crucial for selecting patients who can benefit from corresponding targeted treatments.

There are 8%-12% NSCLC patients have gene fusion mutation. Currently, various tyrosine kinase inhibitors (TKIs) targeting different gene fusions have been approved for clinical treatment. Advanced NSCLC patients with gene fusion-positive can significantly benefit from corresponding targeted therapies. Additionally, multiple studies have shown that receptor tyrosine kinase fusions are one of the mechanisms for acquired resistance in NSCLC patients receiving specific targeted drug treatments. As a result, the NCCN guidelines for lung cancer diagnosis and treatment list anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and rearranged during transfection (RET) as genes that must be tested.

Core Technology:PAP-ARMS®

Applicable Disease:Non-small cell lung cancer

Instruments Validated:ABI7500, ABI7300, ABI StepOne Plus, LightCycler480, Bio-Rad CFX96, etc.

Sample Type:Tumor tissue, Peripheral blood, Pleural effusion

Qualification:ISO13485 certificate, CAP，CE marking

 Pack Size:6 Tests/Kit

Before first-line treatment of inoperable stage III and IV NSCLC patients, common gene detection of lung cancer should be performed, and treatment is recommended to be guided based on molecular classification.

1.Stable and Reliable: It detects with closed tubes to avoid contamination
2.Hight Sensitivity: It detects fusion mutations as low as 100 copies in RNA samples.
3.Comprehensive Coverage: It detects the most common fusion forms of ALK, ROS1 and RET.
4.Fast Results: It takes 1 working day for the hospital / laboratory to complete the detection process.