Therion - Amniotic Tissue for Chronic Wound Care
The Next Generation of Amniotic Tissue for Chronic Wound Care. Therion is a dehydrated and terminally sterilized allograft wound covering derived from human placental membrane. Unlike other amniotic membranes on the market, the proprietary ChAmPion process removes the maternal-derived decidua cells, leaving the amnion and chorion layers in their native configuration. By maintaining the native configuration, higher levels of bioactive compounds are retained compared to a market leading dehydrated human amnion/chorion membrane (DACM).
Chorion has similar bioactives as amnion and is also immune privileged.1,2 By keeping the chorion, the membrane contains more bioactives than amnion alone and provides additional matrix to alleviate the impact of endogenous wound protease activity.3
Therion is safe, effective, and when compared to similar allografts, has excellent handling characteristics. When applied, Therion is:
- Thin and semi-transparent
- Conformal and displays excellent adherence
- Strong and compact yet flexible and less brittle than comparable allograft products
Chronic wounds suffer from an amalgamation of prolonged inflammation and a lack of endogenous tissue inhibitors of metalloproteinases (TIMPs), growth factors, and cytokines. The deleterious imbalance of positive wound healing factors versus negative remodeling moieties prevents the migration of healthy cells into the wound and the synthesis and deposition of extracellular matrix (ECM) components.
Benchtop testing shows that a select group of important bioactives are maintained at high levels in the finished products.1
