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AmorSol - Amorphous Solid Dispersion Technology
AmorSol is a technology for the production of amorphous solid dispersions. Formulation of a drug substance in amorphous form greatly improves its solubility and dissolution kinetics, and has become a standard formulation technique in the pharmaceutical industry for reaching bioavailability goals for poorly water soluble drugs. Amorphous drug substance forms are meta-stable, and can be stabilized by using various polymers to restrict or delay recrystallization of the drug.
Solid dispersions are used to increase the dissolution rate, a limiting factor for the absorption of many compounds in development today. A solid dispersion is a dispersion of the compound in a solid, inert matrix carrier, generally a poorly water soluble drug in a hydrophilic carrier (e.g., a polymer).
Amorphous solid dispersions can be prepared by either a spray-drying (i.e., evaporation of a solvent solution of the drug and polymer), or by hot melt extrusion (i.e., melting of the drug substance with a polymer followed by co-extrusion). For characterization of solid dispersions, Ascendia uses state-of-the-art analytical sciences such as differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), FTIR, and other solid state characterization techniques.
Ascendia’s amorphous solid dispersion technology can enable pharmaceutical products with enhanced bioavailability, reduced food-effect and more rapid onset-of-action.
