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BlueDiver Dot - Model ANA10DIV-24 - Sm - Antibodies Target Spliceosome Components
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Sm antibodies target spliceosome components designated U-snRNP (Uridin-rich small nuclear RiboNucleo-Proteins) that play an important role in mRNA processing. The main Sm antigen is the so-called D1 protein contained in U1, U2, U4, U5 and U6-snRNP. Sm antibodies are diagnostic markers (ACR criterion) for SLE, with very high specificity (99 %) but low sensitivity for the disease.