Laminate - Model VasQ - Arteriovenous Fistula (AVF) Failure Procedure
A biological response to hemodynamic and mechanical stress
Hemodynamic Stress
A turbulent flow profile leads to areas of low wall shear stress associated with development of stenosis or thrombosis 1
Mechanical Stress
Excessive transmural pressure leads to medial hypertrophy1
Inward (Stenotic) Remodeling
The combined effect leads to a high propensity of inward wall thickening of the vein that results in AVF failure for many patients
Promote Outward (Dilative) Remodeling
The nitinol external support controls the remodeling at the anastomosis to promote outward wall thickening downstream for eventual use in hemodialysis.
Optimal Hemodynamics
Produces a more laminar flow transition
Mechanical Support
Structurally reinforces the juxta-anastomotic segment
Retain Control Post-Surgery
Implanted during AVF creation surgery, VasQ retains the optimal configuration of the anastomosis during the critical weeks of maturation post-surgery and beyond.
Venous Tapering
Smoothly transitions flow to the dilated fistula
Arterial Arch
Designed to guide arterial flow towards the vein
In a recent randomized, controlled multi-center study3, more VasQ patients used their fistula for hemodialysis and could discontinue CVC use than patients treated without VasQ.
VasQ patients also had a lower incidence of stenosis or occlusion with consistent outward (dilative) remodelling leading to a greater mean diameter as compared to patients treated without VasQ.
The high AVF usability4 was associated with:
- Greater freedom from >50% stenosis anywhere along the access vein (P=.04)
- Consistent venous dilation above 6 mm for each patient that led to a greater mean diameter (P = .03)