DeltEx DRI - Model INB-200 - Autologous Gamma-Delta T Cell Product

INB-200, our DeltEx DRI, is a genetically modified autologous gamma-delta T cell product candidate for the treatment of solid tumors. This is the first genetically engineered gamma-delta T cell therapy to be administered to patients and our initial indication is newly diagnosed Glioblastoma (GBM). Since 2005 the standard of care treatment for GBM has been surgical resection followed by radiation and chemotherapy, referred to as the Stupp regimen. Currently, the majority of patients relapse in less than one year with very few patients surviving beyond five years. We engineered INB-200 to be resistant to alkylating chemotherapy such that it can be used as an adjuvant with the current standard-of-care to drive improved anti-tumor response. The Phase 1 repeat dose escalation clinical trial of INB-200 is being conducted at the O’Neal Comprehensive Cancer Center at the University of Alabama at Birmingham.