Cerbios - Calcitriol
Cerbios supplies different HPAPI derivatives of Vitamin D3 worldwide. Cerbios has been manufacturing and commercializing HPAPI derivatives of Vitamin D3 since 1993 and is continuously working to develop new products and improve their quality. Calcitriol is a biologically active metabolite of Vitamin D3. The known sites of action of Calcitriol are: intestine, bone, kidney and parathyroid gland. It is the most active known form of Vitamin D3 in stimulating intestinal calcium transport and is highly potent (category 4 SafeBridge). It is also recommended in therapies for the treatment of some autoimmune diseases and certain cancer types (with strict dosage control).
Calcitriol is prescribed for various diseases associated with Vitamin D3 deficiency or related metabolic disorders.
It is used therapeutically for osteoporosis, hyperparathyroidism, renal osteodystrophy, psoriasis, calcium absorption and calcium mobilisation in bone.
Injectable Calcitriol is used in the management of hypocalcaemia in patients undergoing chronic renal dialysis.
Family
- Vitamin D derivatives
Therapeutic area
- Vitamins and antianaemic preparations
- Dermatologicals
- Bone calcium regulators
Synonims
- 1a,25-dihydroxyvitamin D3
- 1a,25-dihydroxycholecalciferol
- (1a,3b,5Z,7E)-9,10-seco-cholesta-5,7,10(19)-triene-1,3,25-triol
- 9,10-seco(5Z,7E)-5,7,10(19)-cholestatriene-1a,3b,25-triol
- (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1a,3b,25-triol
- (1R,3S)-5-{2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
- (1R,3S,5Z)-5-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yliden}ethyliden]-4-methylidencyclohexan-1,3-diol
PROPERTIES
CAS Number : 32222-06-3
Formula : C27H44O3
Molecular Weight : 416.6 g/mol
REGULATORY
FDA : DMF 014718
CEP : 2002-066, 2012-356
Indian DMF : BD-525
Korea DMF : 20180077170(*)
Taiwan DMF : (43)13210
EU : DCP or MR or EFSA
(*) Application ongoing