CAR-T - Cell Therapies for Hematologic Cancers

CAR-T cell therapies are a class of treatments in which T cells are modified to express chimeric antigen receptors (CARs). CARs are engineered molecules that, when present on the surface of a T cell, enable a T cell to recognize a specific protein that is present on the surface of other cells, including cancer cells. Upon recognition of the target cell via the CAR, the CAR-T cell kills the targeted cell. CAR-T cells have demonstrated great success in the clinic, but currently marketed therapies are derived from a patient’s own cells and are therefore available to a limited patient population. We are developing differentiated, off-the-shelf CAR-T cell therapies, derived from healthy donor T cells, that are genome-edited to improve persistence of antitumor activity and potential therapeutic benefit.