Yeasen - Model MW:36000~50000 - Dextran Sulfate Sodium Salt (DSS)

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal infection that increases the risk of intestinal tumors, mainly including UC and Crohn disease (CD). In 1985, after the hamster ulcerative colitis model was first prepared by using DSS, a large number of studies have proved that the DSS colitis model is similar to human ulcerative colitis. The histological features, clinical manifestations, the disease site, and cytokine proliferation of DSS colitis model are very similar to human ulcerative colitis (UC). The modeling conditions and operation methods of this model are simple, the expenditure is very cheap, the repeatability is good, and it is easy to master and popularize. The DSS concentration and dosing time can be adjusted according to the experimental purpose to establish acute, chronic and acute-chronic alternation models.

• The protocols are easy to be implemented.
• The DSS UC model closely resembles human UC symptoms with high repeatability.
• Various characteristic symptoms can be induced by controlling the administrated DSS dose, which was unique for the DSS UC model.
• The DSS UC model can be generated with a variety of widely used model animals, such as mice, rats, zebrafish, pigs, fruit flies, etc.
• The IBD-induced colitis-associated cancer (CAC) model can be created with the combined use of azoxymethane (AOM).

• For modeling colitis

• English synonym : Dextran Sulfate Sodium Salt, DSS; Dextran Sodium Sulfate
• CAS NO. : 9011-18-1
• Formula : (C6H7Na3O14S3)n
• Appearance : White or off-white powder
• Solubility : Soluble in water, slightly soluble in ethanol.