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- Locus - Discovery Automation Technology
Locus - Discovery Automation Technology
Utilizing high-throughput liquid handlers, Locus is able to rapidly identify and characterize bacteriophage libraries against any bacterial target. Our team collects natural bacteriophages from the environment and uses a high-throughput robotic platform to isolate and characterize phages with the desired properties. Selected phages are combined into cocktails that can kill the clinically-relevant strains of the target bacterial species. We screen phages against target strains using a proprietary high-throughput system to quickly identify a cocktail with optimized activity across thousands of pathogenic isolates to serve as the starting point for an engineered phage cocktail.
Next-generation sequencing (NGS) technology enables Locus to rapidly capture the genomic sequence of each phage.
Having complete genomic sequences for both the phage products and their bacterial targets allows us to thoroughly understand the genetics of these organisms. Paired with the phenotypic characteristics captured during high-throughput characterization, we can rapidly identify and select bacteriophages for engineering. Moreover, our database containing thousands of bacteriophage genomes and phenotypic characteristics enables us to understand bacteriophage better than anyone else.
