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GelmetixDouble Cross-Linked Microgel (DXM)

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A focus on low-back pain. About 40% of chronic low-back pain is the result of degenerative disc disease3. Gelmetix’s double cross-linked microgel (DXM) is a biological solution that addresses the source of pain. In the intervertebral disc it restores water content and helps cells to return to normal function1. Our product is not a drug.

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  • Fills gap in the chronic low-back pain treatment continuum
  • Minimally invasive
  • Short learning curve
  • Single-injection & fast treatment with sustained relief of pain
  • Restores the disc to close-to-normal function
  • Limited associated risks

DXM addresses the shortcomings of the following existing treatment options4, none of which affect the mechano-biological root cause of pain:

Painkillers
  • Painkillers may be the best option for many patients with light back pain. However, these often do not appropriately relieve chronic low-back pain; NSAIDs and steroids are associated with potentially severe side effects and dependency. None of these will ever tackle the mechano-biological root cause of the pain.

Physical therapy, acupuncture, diet, yoga
  • These therapies are effective at relaxing muscles, thus providing some pain relief or at least modifying the perception of the pain. Studies show that they do not improve the disability associated with low-back pain.


Electrostimulation
  • The application of targeted electrical stimulation to the area of the painful lower back helps the patient not to feel pain. While it works for many pain sufferers, it only provides short-term pain relief with limited efficacy for chronic low-back pain. Sometimes, even implantation of wires close to the targeted nerves or muscles is needed.

The nucleus pulposus is located at the center of the disc, which is located between two vertebrae. It acts a shock absorber and a fulcrum for motion thanks to its water content6.

Recent advances in the study of the nucleus pulposus help us to understand its functioning and what happens when it doesn’t work well7.

The nucleus is a complex tissue with many active mediators, communicating with its environment and other nucleus cells7.

High in water content

  • Brings water to the extracellular matrix
  • Restores water content of the nucleus pulposus
  • Restores hydrostatic pressure needed by the NP cells to function normally
  • Stable under load pressure

Good distribution

  • Good distribution within the NP’s extracellular matrix – fills proteoglycan and collagen depleted zones

Well-contained

  • Is well-contained by the annulus fibrosus, which is mechanically effective at the early stage of the degenerative process

DXM is a pH-responsive, double cross-linked hydrogel, which is designed to supplement the existing nucleus pulposus1.

DXM seeks to act as a substitute to compensate for the progressive degradation of the proteoglycan matrix of the nucleus.

DXM has the mechanical properties to restore and maintain disc height and is suitable for restoring close to a normal dynamic pressure environment within the disc. It restores the mechanical conditions with favourable effect on nucleus cell biology that contributes to the relief of pain as it restores the normal function of the nucleus cells.

DXM fills an unmet gap in the treatment continuum between conservative and surgical methods that has the potential to provide significant pain relief for patients, slow the progression of the disease and reduce the need for more invasive surgical intervention.