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Amikacin Cyclops - Dry Powder Inhaler
Amikacin Cyclops™ is an amikacin dry powder inhaler for the treatment of tuberculosis (TB). Inhaled amikacin from the Cyclops™ will result in higher amikacin concentrations in the lungs than conventional infusion or intramuscular injection. This could more rapidly decrease contagiousness by sterilizing the upper airways of patients with ’open’ (smear positive) TB, potentially even of otherwise drug resistant TB. In addition, Amikacin Cyclops™ offers TB patients an easier and much more convenient administration than infusion or injection. A fast reduction of contagiousness and new, less toxic drug regimens with a shorter duration will prevent long hospital admissions and thereby help to reduce healthcare costs.
Amikacin is an approved drug for the treatment of and non-tuberculous mycobacterial infections. Amikacin is not absorbed via the gastrointestinal tract, which makes its oral administration impossible. TB is the world’s most common infectious disease that caused a staggering 1.4 million deaths in 2019 (WHO). Therefore, stopping the spread of TB and improving its treatment are urgently required. Inhaled, more targeted treatment with inhaled amikacin from the Cyclops™ may aid in battling the often-unrecognized humanitarian disaster TB causes on a global scale.
An open-label Phase 1 clinical trial with Amikacin Cyclops™ in TB patients is currently ongoing to determine its pharmacokinetics and local tolerability.