MammaTyper - Model ESR1 - Estrogen Receptor 1 Gene Biomarker

The Estrogen receptor 1 gene (ESR1) belongs to the family of steroid receptors. The protein is expressed intracellularly. It is a transcription factor regulating the expression of genes and is activated by estrogen. Estrogen receptors are overexpressed in about 70 % of all Breast Cancer cases. There are hypotheses, that overexpression causes tumourigenesis. ESR1 overexpressing tumours can be treated with endocrine therapies such as tamoxifen (ESR anatagonist) or anastrozol (aromatase inhibitor).