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Ceveron - Model s100 - Fully Automated Coagulation Analyzer
The first, fully automated haemostasis analyzer for measuring classical haemostasis parameters, thrombin generation, Factor XIII activity and ADAMTS13 activity, at the same time on one instrument. 15 years ago, Technoclone launched the first ADAMTS13 test kit. With adding the Quenching module to our Ceveron instrument platform, Technoclone’s innovation now advances to run fully automated ADAMTS13 Activity as simple as a PT, on the new Ceveron s100. Without switching the instrument, or the patient sample, you can receive an ADAMTS13 Activity result in less than 30 minutes. With no more space needed than our first generation Ceveron alpha, we have refined our Ceveron 100 series platform into the perfect solution for your haemostasis speciality testing, without loosing focus on routine assays.
Quenching technology is based on high sensitive fluorescence measurement.
Different ways of quenching methods, like dynamic quenching such as Förster resonance energy transfer (FRET), or static quenching which can be used.
Currently available parameters using the Quenching module:
- In the Technofluor Factor XIII Act test the quenching method employs a molecule that is bound to a peptide which is cleaved by FXIIIa. Subsequently, the fluorescence of this quen-ching molecule increases and can be monito-red by the Ceveron s100 Quenching module.
- The Technofluor ADAMTS13 Act test uses FRET technology. Due to the quenching reac-tion the donor fluorophore is activated, and transfers it´s energy to the quenching molecule which is emitting light. The measured fluorescence signal is proportional to the amount of VWF cleaved by ADAMTS13.
Time and cost saving
- Available 24/7 with benefits for patients, saving valuable plasma and financial resources
Easy
- Running a Factor XIII Activity or ADAMTS13 Activity sample is as easy, as running a routine coagulation sample
Fast
- Fully automated ADAMTS13 Activity result in less than 30 minutes.
- Quenching module using parameters can be run in paralell to all other parameters including TGA.
- STAT samples processing is also available using the Quenching module
- Lot stable calibration curve with a high linearity