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EndoClearModel Plus - Human Recombinant a-Synuclein Protein

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α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson`s disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.

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*For more stringent applications, EndoClear™Plus offers the lowest endotoxin research grade alpha-synuclein protein available in the market.

Full-length Recombinant human alpha-synuclein (GenBank Accession # NP_000336) was expressed in E. coli., and purified from bacterial lysate using proprietary method. Endotoxin was further removed by proprietary technique. Molecular weight of the recombinant α-synuclein protein is 14.5 kDa.

  • Chemistry
    • UniProt number: P37840
    • Molecular Mass/ Weight: 14.5 kDa
  • Modification
    • Conjugation: Unconjugated
  • Quantity & Purity
    • Concentration: none (lyophilized)
    • Purification Method: Purified
    • Purity: ≥95% by SDS-PAGE
    • Endotoxin content: < 0.001EU/ug protein
  • Storage & stability
    • Form: Lyophilized
    • Storage Buffer: The purified a-synuclein is supplied as lyophilized powder nearly salt free.
    • Storage Conditions: Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 12 months. Avoid repeated freeze-thaw cycles
  • Activity
  • Application:
    • Aggregation/Fibrillation ELISA
    • Western Blotting
  • Biomarker Target: Synuclein
  • Specificity: human a-synuclein (1-140)
  • Research Area: Neuroscience
  • Sub-category Research Area: Parkinson`s Disease
  • Usage: Research use
  • Source
    • Host: E. coli
    • Source / Species: human
  • Codes
    • Code Nacres: NA.27