North American Science Associates Inc.(NAMSA )

Extherid - Human Skin

FromNorth American Science Associates Inc.(NAMSA )

We use our human skin model to test lead formulations and screen them against a variety of parameters in human skin to ensure clinical success. We perform antimicrobial efficacy testing, biomarker assessments, and host cell toxicity on wounded or unwounded skin.

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To assess inflammation we treat and incubate intact skin, take biopsies from the treated intact skin, and then perform ELISAs or cytokine panel assays to determine quantities of biomarkers.
To test for efficacy against known human pathogens, experiments are typically performed on wounded skin explants. These explants are prepared by removing a small amount of epidermis from the center of a larger explant. The depth and size of these explants and wounds are customizable.
We also assess wound healing in the wounded skin model. At specific timepoints post-treatment, we analyze the biomarkers present in wounds and couple that data with histology.

Extherid - Human Skin

Model Overview