Pion - Model Scissor N3 - In-Vitro Subcutaneous Injection Site Simulator
The Scissor N3 is an advanced in vitro model designed to simulate the subcutaneous injection of biopharmaceuticals. This device is particularly useful during the formulation development phase, enabling researchers to perform rank ordering of formulations and excipient screening. It allows for a thorough understanding of how a drug behaves post subcutaneous injection and its subsequent release, thus reducing the dependence on less accurate animal models. This system offers a bio-relevant environment where researchers can observe precipitation events and correlate them to lymphatic and systemic release rates, saving both time and costs in drug development. The Scissor N3 is compatible with the Rainbow R6 in-situ fiber optic UV-vis spectrometer for real-time data collection and an optional fraction collector for offline analysis. The system supports various extracellular matrices, including ECM A and ECM-XR, providing flexibility for testing immediate and sustained release formulations. This technology ensures more reliable and earlier selection of promising formulation candidates.
Scissor N3 is an in vitro model simulating subcutaneous injection of biopharmaceuticals for rank ordering formulations and excipient screening during formulation development.
- Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.
- Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.
- The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.
- Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.
- Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.
- Compatible with an optional fraction collector
The Scissor N3 is an exciting branch of the Pion technology helping users understand formulations
- Excipient screening during formulation development
- Formulation comparison
- Rank ordering formulations for candidate selection
- Investigation of drug stability upon and after injection
Extracellular matrices
ECM
A hyaluronic acid-based viscous liquid dynamically created to mimic the human subcutaneous space for 24-hour long assays for immediate release formulations.
ECM-XR
A hydrogel containing hyaluronic acid constructed to simulate the human subcutaneous space for up to a week aimed towards long-acting injectables for sustained release formulations.