
Taconic Biosciences, Inc.
- Home
- Companies
- Taconic Biosciences, Inc.
- Products
- Taconic - Model Black 6 (B6NTac) - ...

Taconic - Model Black 6 (B6NTac) - Inbred Mouse Model
One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it`s commonly used as the genetic background for transgenic mouse models. It is also the preferred model for studying diet-induced obesity and the chronic experimental autoimmune encephalomyelitis model of multiple sclerosis.
Most popular related searches
metabolism disease
oncology immunology
sperm fertility
sperm fertilization
fertility rate
multiple sclerosis
retinal degeneration
stem cell
degeneration retinitis
cesarean
- Popular research applications include oncology, immunology, metabolic disease, addiction and toxicology
- C57BL/6NTac is the preferred C57BL/6 substrain for generation of genetically engineered models, including by the Knockout Mouse Project (KOMP) and International Mouse Phenotyping Consortium (IMPC)
- The Taconic B6 has superior reproductive performance compared to other B6 substrains: superovulated females yield a high number of embryos and males have higher sperm fertilization rates
- The Taconic C57BL/6NTac has proven more amenable to the development of quality embryonic stem cells compared to other B6 substrains
- Popular strain for syngeneic tumor experiments; with a suite of related strains on the same background for mechanistic studies including Rag2, Rag2/OT-I, Rag2/OT-II and many more
- Historical data shows that hydrocephaly occurs in the C57BL/6 mouse in 0.05% of the population and may not be evident until the animal is more than two months of age.
Origin:C57BL/6 litters were received in 1991 at F151 from the NIH Animal Genetic Resource. Cesarean derived in 1991 at Taconic, a foundation colony is maintained in gnotobiotic isolators. Origin is as follows: to NIH in 1951 from Jax at F32; to Jax in 1948 from Hall.
Availability:Available at the Murine Pathogen Free™, Opportunist Free™, and Germ Free health standards. Order model #B6 for Murine Pathogen Free™ and Opportunist Free™. Order model #GF-B6 for Germ Free. Inquire about ordering mice positive or negative for Segmented Filamentous Bacteria (SFB).
Genetics:
- Strain Profile: Acy1f, Aladb, Car2a, Cas1g, Cd5b, Cd72b, Cd8ab, Cd8b1b, Ce2a, Es1a, Es3a, Esda, Ggc1b, Gpi1b, Gus-sb, H6pd1b, Hbaa, Hbbs, Hc1, Idh1a, Mod1b, Mup1b, Pep3a, Pgm1a, Trfb
- Immunology: H2b, Ptprcb, Thy1b, H2-T18b
- Retinal Degeneration: Crb1Rd8
Coat Color Loci:a/a, B/B, C/C
Color:Black
Species:Mouse
Animal Diet:NIH #31M Rodent Diet