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Virpax Pharmaceuticals
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Virpax - Model Probudur - Injectable Long-Acting Bupivacaine Hydrogel

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Ultra-Long-Acting Local Anesthetics: Liposomal Encapsulated Bupivacaine; Sustained Non-Opioid Pain Management in Prolonged Field Care and Hospital Settings.

Most popular related searches
local anesthetic
postoperative pain
post-surgical pain
pain management
surgery pain
analgesic administration
postoperative analgesia
opioid pain
nerve impulse
nerve damage

TARGET MARKET
Local anesthetic post-surgical pain market

DELIVERY SYSTEM
Liposomal in hydrogel encapsulation

POTENTIAL BENEFITS

  • Single dose infiltration into the surgical or wound site
  • Prolonged postoperative analgesia effect for 96 hours
  • May eliminate the need for opioids after surgery
  • May reduce associated costs and length of hospital stay
  • Produced no evidence of motor or sensory nerve damage at a dose that was 10 times higher than free bupivacaine in animal studies
  • Animal studies demonstrated 96 hours of local anesthetic activity at wound site
  • Local anesthetics prevent the transmission of painful nerve impulses and are an integral component of postoperative pain management
  • Most available local anesthetics have a short duration of action necessitating opioid and other analgesic administration following surgery
  • Local anesthetics are relatively small molecules (<400D) and therefore are rapidly redistributed from their site of administration- limiting their duration of action
  • The risk of systemic toxicity from local anesthetics limits the dose that can be safely administered
  • There is a compelling need for an ultra-long-acting local anesthetic that would provide prolonged pain relief with a single administration
The co-developer of Doxil and a world-leading liposome researcher
  • Encapsulation of the local anesthetic bupivacaine into large multivesicular vesicles (LMVV or Bupisome) has been shown to be an effective means of prolonging analgesia
  • Probudur is an ultra-long-acting 3% bupivacaine liposomal gel under development for the management of postoperative pain
  • The prolonged retention of the LMVV at the site of administration extends the duration of action up to 96 hours
  • The slow release of the drug from the liposomal depot reduces the peak plasma levels, and therefore, the toxicity or trauma
  • This allows potential administration of higher bupivacaine doses for the management of pain after surgery