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GENERI BIOTECH - Model gb HEMO FII (G20210A) - IVD Kit for Thrombophilic Mutations
Detection method: allelic discrimination, real-time PCR; This in vitro diagnostic kit is intended for detection of mutation G20210A in coagulation factor II in human genomic DNA. Detection is based on real-time polymerase chain reaction (qPCR) using fluorescently labelled probes (allelic discrimination).
Coagulation factor II (prothrombin) is a glycoprotein involved in the process of blood coagulation. Prothrombin is converted to thrombin, which cleaves fibrinogen to fibrin monomers (necessary for blood coagulation). G20210A mutation is located in the prothrombin gene promotor region and causes prothrombin overactivation which leads to increased risk of blood clot creation.
- ready-to-use assay
- sample concentration 1-100 ng/µl
- positive and negative controls included
- FAM and HEX channels detection
- identical amplification profile as gb HEMO, gb GENETIC, gb PHARM kits
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