Model LPS Series - Lipopolysaccharide

Sepsis is a systemic inflammatory condition associated with the presence of pathogenic microorganisms or their toxins in the blood. Symptoms associated with the presence of circulating endotoxin include fever, hypertension, and, under more extreme cases, endotoxic shock and death. Lipopolysaccharide (LPS) is an endotoxin, an outer membrane component of Gram negative bacteria involved in the sepsis pathology that is responsible for toxic activity. LPS challenge leads to acute inflammation and elevation of the pro-inflammatory cytokine levels.