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osteomiR - microRNA Biomarkers Kit of Bone Quality
FromTAmiRNA GmbH
The osteomiR® test enables parallel measurement of 19 carefully selected and validated microRNA biomarkers of bone quality in human serum samples. The osteomiR® software can be used for individual analysis of all 19 microRNA biomarkers, as well as for the calculation of a fracture-risk score. This score is based on multivariate microRNA model.
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- One-stop-shop solution to start microRNA bone and muscle research
- Contains all quality controls required to perform high quality microRNA bone biomarker research
- A single kit allows analysis of 19 osteomiR® microRNA bone quality biomarkers in up to 48 samples
- Cross-species application is possible due the high sequence conservation
- Assess bone quality using the osteomiR® score
- Frozen platelet poor plasma (PPP) aliquots of at least 200 µl
- qPCR instrument (read the manual to find out which instruments are supported)
- High throughput: Analysis of up to 48 serum samples
- Low sample volume: 200 µL human serum (lower volumes can be used but require pre-testing), deep-frozen (-70°C or lower) serum samples can be used (stability for several years has been demonstrated)
- Reduced hands-on time and technical varibility: primer coated 96 or 384 well plates
- 19 osteomiRs and 5 quality controls are measured per sample
- Fast and simple data analysis: the web-based osteomiR® software application enables easy data normalization and quality control
- Standardized analysis of qPCR data
- Import: upload of raw data files from qPCR instrument and automatic Cq-value calling
- Quality Control: inspect amplification curves, melting temperature, spike-in and hemolysis controls
- Normalization: correction of technical variance and optional imputation of missing values
- Export: export normalized Cq-values of all samples and combine automatically with clinical parameters (i.e. age, gender, etc.)
The osteomiR® analysis toolkit and further information will be made available to all registered customers of the osteomiR® kit.
The osteomiR® panel was designed based on a series of research studies, which provide evidence that osteomiRs
- are associated to bone microstructure and histomorphometry
- are regulated in patients with osteoporotic fractures
- are BMD-independent risk factors for osteoporotic fractures
- regulate bone formation and resorption via multiple pathways
- are novel biomarkers for bone diseases