Milling
Both pin and hammer mills are distinguished for their robustness and versatility, handling a wide variety of materials. These mills are not only effective in reducing particle size but also promote better mixing and homogenization of the formulation components. This is crucial in pharmaceutical applications where the consistency of particle size affects not only the bioavailability and efficacy of the drug but also its manufacturability and stability.
Cryo milling is another notable technique used across these industries for materials that require careful handling to prevent degradation at higher temperatures.
Understanding and optimizing milling conditions according to the specific properties of the material and the desired final product characteristics are vital in achieving optimal product quality and ensuring therapeutic effectiveness.
A pin mill consists of two discs facing each other; one is stationary while the other rotates at high speeds. The rotating disc is equipped with pins that collide with the particles. This collision results in particle fragmentation. The centrifugal forces generated by the spinning action propel the particles outward from the center of the disc to the periphery, ensuring further size reduction. This type of mill is known for its ability to achieve uniform particle sizes and a high level of fineness, which can be adjusted by altering the speed of the rotor and the proximity of the discs. It is particularly beneficial for materials that require delicate treatment or intensive grinding.
Cryo MillingCryo milling is a specialized technique that involves cooling materials to cryogenic temperatures before and during the milling process. By making the materials brittle, they can be fractured more easily with minimal energy. This method is particularly useful for processing temperature-sensitive or difficult-to-mill materials, as it prevents thermal degradation and preserves the structural integrity of the material. Industries dealing with complex materials like polymers, certain metals, and temperature-sensitive organic compounds benefit from cryo milling`s capacity to maintain the quality and functionality of the end product.
In contrast, a hammer mill employs a series of hammers typically mounted on a rotating shaft. As the shaft spins, the hammers swing outward, striking the particles and breaking them apart upon impact with the hammers or the mill casing. This impact leads to size reduction. The particle size output can be controlled by the speed of the rotor, the size and number of hammers, the configuration of the grind plates, and the screen size used at the discharge area of the mill. It`s a go-to choice for industries that require rugged equipment capable of handling diverse particle size reduction tasks.