Myeloid Therapeutics
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Next-Generation Delivery and Editing Technology

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Retrotransposons are genetic elements that can replicate through reverse transcription of an RNA transposition intermediate. They contribute to structural changes and, more importantly, to gene regulation. Our proprietary RNA-based, retrotransposon-mediated gene-insertion technology (CREATE) has applications across gene editing and delivery.

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Expanding the Ability to Reverse Genetic Errors in Situ

Our retrotransposon-based approach utilizes mRNA to deliver genetic sequences and integration enzymes in a single mRNA strand. This technology offers the potential to deliver gene-sized pieces of DNA into the genome — larger than currently possible with existing gene editing technologies.