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TransgeneModel TG6002 - Oncolytic Virus

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A new generation of multifunctional oncolytic virus, TG6002 has been designed to combine the mechanism of oncolysis (targeted destruction of the cancer cell) with the production of chemotherapy (5-FU), directly into the tumor.

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Attacking the tumor on several fronts

TG6002 combines several mechanisms of action to:

  • directly and selectively destroy the cancer cells (oncolysis) by causing immunogenic cell death;
  • induce an immune response, following the release of antigens during the oncolysis;
  • allow the production of chemotherapy (5-FU), directly in the tumor.
First promising results

Transgene is developing TG6002 for the treatment of several solid tumors, such as gastro-intestinal adenocarcinoma (stomach, pancreas and colon). Phase I interim results demonstrate that after IV infusion, TG6002 was detected in the tumor and induced the production of 5-FU. No major SAE have been observed.

Sale of the rights in China

Tasly Biopharmaceutical Group Co, Ltd. acquired research, development and commercialization rights of the technology of TG6002 (T601) for Greater China in 2018.