Star - Model OLZ - Parpi Induced Nausea And Vomiting (Piinv)

STAR-OLZ is a 7-day transdermal patch in development as the first product indicated for PARP inhibitor (PARPi) induced nausea and vomiting (PIINV). PARP inhibitors are a rapidly growing class of cancer therapies currently used in ovarian and breast cancer maintenance therapy, and expected to expand into prostate, pancreatic, lung, and other solid tumors. Nausea and vomiting occur in 77 and 36% of patients respectively, existing antiemetics are contraindicated for use with PARP inhibitors or are not suited for long-term use. Olanzapine is a proven antiemetic, but currently available forms have not been widely adopted in the PARP inhibitor treatment setting due to fear of side effects. STAR-OLZ is designed to improve quality of life and outcomes by controlling PIINV without significant side effects.