CytomX - Model CX-072 - PD-L1 - Targeting Probody Therapeutic

CX-072 is a wholly owned PD-L1-targeting Probody therapeutic for the treatment of cancer. Initial clinical data presented at the ASCO and ESMO 2018 Annual Meetings showed that CX-072 demonstrated tolerability and anti-tumor activity, while reducing activation of the immune system outside the tumor. Initial clinical translation data presented at SITC confirmed that CX-072 is unmasked, activated and has biological activity in patient tumors while remaining predominantly masked and intact in circulation. Following a recent program and portfolio prioritization, CytomX has also made the strategic decision to terminate the Phase 2 trial of the anti-PD-L1 Probody CX-072 in combination with Yervoy® (ipilimumab) in melanoma. This allows CytomX to focus on its potential first-in-class assets, including the combination of CX-072 and CX-2009.