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PathPlus - Model LS-A2099 - Polyclonal Rabbit anti-Human LTB4R2 / BLT2 Antibody (Cytoplasmic Domain, IHC)
LTB4R2 is a low-affinity receptor for leukotrienes including leukotriene B4. It mediates the chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. LTB4R2 has been found to be overexpressed in esophageal squamous cell cancer and may be involved in the early stages of carcinogenesis. In immunohistochemistry, LTB4R2 has membranous positivity in the spleen, thymus, tonsil, and lymph nodes, and is found on lymphocytes, macrophages, and potentially neutrophils.
Target
Human LTB4R2 / BLT2
Synonyms
LTB4R2 | BLT2 | BLTR2 | Blt-2 | BLT2R | JULF2 | LTB4-R2 | Hblt2 | KPG_004 | Leukotriene B4 receptor 2 | Leukotriene B4 receptor BLT2 | LTB4 receptor JULF2 | LTB4-R 2
See All LTB4R2 / BLT2 Antibodies
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human LTB4R2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Mouse, Rat, Bat (88%); Elephant (81%).
Epitope
Cytoplasmic Domain
Specificity
Human LTB4R2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
It is also present on neuronal subsets in the caudate nucleus, globus pallidus, subiculum, hippocampus, amygdala and tuberal nucleus within the central nervous system. It is positive in a wide range of cancers, including glioblastoma, breast cancer, colorectal adenocarcinoma, pulmonary adenocarcinoma, Hodgkin`s disease, ovarian cancer, pancreatic cancer and lamignant melanoma.
References: BMC Gastroenterol 16, 85 (2016), doi:10.1186/s12876-016-0499-z
- Antibody: LTB4R2 / BLT2 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
- Application: IHC, IHC-P, IHC-Fr, Flo
- Reactivity: Human, Monkey
- Format: Unconjugated, Unmodified
- IHC
- IHC - Paraffin (26 µg/ml)
- IHC - Frozen
- Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee